S3 Ventures is a U.S.-based venture capital firm founded in 2005 and headquartered in Texas, investing in technology companies across the United States.

The firm focuses on early to mid-stage investments, primarily in business software and healthcare technology.S3 Ventures typically leads Seed, Series A, and Series B rounds, with initial investments ranging from approximately $500K to $15M and the ability to deploy up to $25M per company over its lifecycle.The firm operates with a single limited partner, a philanthropic family foundation, which allows S3 Ventures to invest without ongoing fundraising activities and maintain a long-term investment approach.