Aposense is a publicly traded Israeli biopharmaceutical company specializing in developing innovative drugs that use the structural and electrical properties of biological membranes.The companys proprietary technology is built around the powerful electrical field that resides deep within any phospholipid membrane.

Aposense has developed a way to use this resource to energize molecular binding reactions for various medical applications, including imaging of cell death; formation of intramembrane drug depots for sustained release; and transmembrane delivery of macromolecules, such as DNA, siRNA, or therapeutic proteins.Aposense has designed and developed electrical molecular nano motors (MNMs), pharmaceutically compatible, small-molecule chemical moieties (MW700 Daltons) capable of moving within the core of cell membranes in response to the internal electrical field.

The MNMs are able to convert the potential energy of the internal membrane electrical field into kinetic energy and move within the membrane while exerting beneficial pharmacological effects.By combining Aposense MNMs with a macromolecule drug, the drug can be efficiently delivered across cell membranes.

Furthermore, a proprietary molecular switch is integrated within the MNMs.

It is selectively activated upon entry into the cells, and acts to release and liberate the intact macromolecule drug in the cytoplasmatic compartment to exert its biological action.